Aaron M. Miller, MD, PhD

Aaron M. Miller, MD, PhD, is a board-certified medical oncologist who specializes in diagnosing and treating gastrointestinal cancers. This includes cancers of the esophagus, gallbladder, liver, pancreas, stomach, small intestine, bowel and anus. He uses numerous forms of therapy such as chemotherapy, biological therapy, immunotherapy and targeted therapy to offer the best possible treatment options for his patients.

Dr. Miller's approach to care emphasizes personalized medicine/precision oncology, adoptive cellular therapy, next-generation tumor sequencing and tumor immunology. He is part of the gastrointestinal cancer unit at Moores Cancer Center at UC San Diego Health, where he works alongside a multidisciplinary team to provide patients with highly specialized care. He is also part of UC San Diego Health's Precision Immunotherapy Clinic, which offers the most promising investigational immunotherapy treatments for many types of cancer.

Dr. Miller is an associate professor in the Department of Medicine, where he instructs medical students, residents and fellows at UC San Diego School of Medicine. He holds a joint faculty appointment at the La Jolla Institute for Allergy and Immunology and is actively involved in cancer research, with the aim of translating his discoveries in the lab into new ways of treating patients.

Specifically, Dr. Miller's research focuses on tumor neoantigen identification as targets for novel immunotherapeutics that are both effective and avoid off-tumor toxicities. He and his colleagues have also created a new patient-derived xenograft platform that allows for preclinical testing of investigational chemotherapeutics and immune therapies. He has co-authored several peer-reviewed articles and his work has appeared in Nature Medicine and Advanced Drug Delivery Reviews, among others.

Dr. Miller completed a fellowship in hematology-oncology at UC San Diego School of Medicine, where he also completed a residency in internal medicine. He earned his medical degree from the Feinberg School of Medicine and a doctoral degree from the Graduate School, both at Northwestern University. Dr. Miller is board-certified in internal medicine and medical oncology.

He is a member of numerous professional organizations, including the American Society of Clinical Oncology, the American Association for Cancer Research and the American Medical Association.

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For more information, see Gastrointestinal Cancers, Precision Immunotherapy Clinic, Cancer Care.